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Subramanian, S.
- Biochemical Evaluation of Antidiabetic Activity of Piper Betel Leaves Extract in Alloxan-induced Diabetic Rats
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1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai – 600025
2 Mahatma Gandhi Medical College and Research Institute, Pondicherry – 607402
1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai – 600025
2 Mahatma Gandhi Medical College and Research Institute, Pondicherry – 607402
Source
Asian Journal of Research in Chemistry, Vol 6, No 1 (2013), Pagination: 76-82Abstract
Globally, majority of cultures directly uses plants as medicines as they are rich sources of drugs. Piper betel Linn. (family Piperaceae) commonly known as the betel vine and has a long history of over 2000 yrs. Betel leaf is traditionally known to be useful for the treatment of various diseases. In the absence of systemic studies in the literature, the present study was aimed to evaluate the antidiabetic potential of Piper betel leaves in alloxan-induced experimental diabetes in rats. The altered levels of biochemical parameters such as blood glucose, plasma insulin, haemoglobin, glycosylated haemoglobin, liver and muscle glycogen content, protein, urea, creatinine, uric aicd, AST, ALT and ALP in the diabetic rats were significantly reverted upon oral administration of Piper betel leaves extract for 30 days. The levels of lipid peroxides in the plasma and pancreas of diabetic rats were elevated significantly and were normalized by the administration of Piper betel leaves extract. The activities of pancreatic enzymic antioxidants and the levels of plasma nonenzymatic antioxidants were markedly declined in the diabetic rats. Upon treatment with leaves extract to diabetic rats, these decreased antioxidant levels were significantly improved. Further, the altered levels of lipid profile were significantly improved upon treatment with leaves extract. The results of the study indicates that Piper betel leaves possess antidiabetic activity and the results were comparable with gliclazide, an oral standard hypoglycemic drug. The phyto-constituents present in the leaves may account for the observed pharmacological properties.Keywords
Medicinal Plant, Diabetes, Piper Betel, Antidiabetic, Alloxan
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- Antidiabetic, Antilipidemic and Antioxidant Nature of Tridax procumbens Studied in Alloxan-Induced Experimental Diabetes in Rats:A Biochemical
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Authors
Affiliations
1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, IN
1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1732-1738Abstract
Diabetes mellitus is a chronic disorder associated with derangements in carbohydrate, lipid and protein metabolism. Tridax procumbens is employed as an indigenous medicine for a variety of ailments. The present study was aimed to evaluate the hypoglycemic, hypolipidemic and antioxidant properties of Tridax procumbens leaf extract in alloxaninduced experimental diabetic rats. The effect of oral administration of Tridax procumbens leaves extract (400 mg/kg b.w.) on the levels of blood glucose, glycosylated hemoglobin, plasma insulin, urea, uric acid, creatinine, protein, lipid peroxides, enzymatic and non-enzymatic antioxidants, lipid profile were determined in control and experimental groups of rats. The altered levels of blood glucose, hemoglobin, glycosylated hemoglobin, plasma insulin, urea, uric acid, creatinine and protein in the diabetic rats were significantly reverted back to near basal values by the administration of ethanol extract of Tridax procumbens leaves extract to diabetic rats for 30 days. The levels of lipid peroxides in the plasma and pancreatic tissues of diabetic rats were elevated significantly and were normalized by the administration of Tridax procumbens leaves extract. The activities of pancreatic enzymic antioxidants and the levels of plasma non-enzymic antioxidants were markedly declined in the diabetic rats. Upon treatment with Tridax procumbens leaves extract to diabetic rats, these decreased levels were elevated to near normal values. The altered levels of lipid profile were reverted back to near normalcy upon the extract treatment. The results of the study indicate that Tridax procumbens leaves extract possesses antilipidemic, antioxidant effects in addition to antidiabetic activity. The results are comparable with glyclazide, an oral standard hypoglycemic drug. The phytochemicals present in the Tridax procumbens leaves extract may account for the observed pharmacological properties.
Keywords
Diabetes, Tridax procumbens, Antidiabetic, Antilipidemic, Antioxidant Nature.- Biochemical Evaluation of Hypoglycemic Activity of Musa paradisiaca (Plantain) Flowers in STZ-Induced Experimental Diabetes in Rats
Abstract Views :205 |
PDF Views:0
Authors
Affiliations
1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, IN
1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, IN